Title of article
Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line
Author/Authors
Cavalcanti، نويسنده , , B.C. and Moura، نويسنده , , D.J. and Rosa، نويسنده , , R.M. and Moraes، نويسنده , , M.O. and Araujo، نويسنده , , E.C.C. and Lima، نويسنده , , M.A.S. and Silveira، نويسنده , , E.R. and Saffi، نويسنده , , J. and Henriques، نويسنده , , J.A.P. and Pessoa، نويسنده , , C. and Costa-Lotufo، نويسنده , , L.V.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
388
To page
392
Abstract
The genotoxic effect of two tanshinones isolated from roots of Hyptis martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung) cells by the alkaline comet assay and micronucleus test. Tanshinones were incubated with the cells at concentrations of 1, 3, 6 and 12 μg/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic against V79 cells at all tested concentrations. The data obtained provide support to the view that tanshinones has DNA damaging activity in cultured V79 cells under the conditions of the assays.
Keywords
Comet assay , Micronucleus test , Hyptis martiusii , Tanshinones , Plant diterpene
Journal title
Food and Chemical Toxicology
Serial Year
2008
Journal title
Food and Chemical Toxicology
Record number
2119550
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