Title of article :
Co-factors for abnormal lactate levels among persons with HIV disease at a tertiary HIV care setting in South India
Author/Authors :
Sundaram، نويسنده , , Muthu and Srinivas، نويسنده , , Chakravarthy Narasimhachar and Shankar، نويسنده , , Esaki Muthu and Deepak، نويسنده , , Manohar and Murugavel، نويسنده , , Kailapuri G. and Balakrishnan، نويسنده , , Pachamuthu and Solomon، نويسنده , , Suniti and Kumarasamy، نويسنده , , Nagalingeswaran، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
3
From page :
2823
To page :
2825
Abstract :
Background: -factors underlying abnormal lactate level remains to be determined in resource-limited settings. In a cross-sectional study conducted between January 2004 and July 2006, we determined the proportion of HIV-infected persons with abnormal lactate levels and correlated the association of certain co-factors of abnormal lactate levels at a tertiary HIV care centre in Chennai, Southern India. s: e was estimated by the enzymatic method using an Olympus AU 400 autoanalyzer. Absolute CD4 + T lymphocyte count was determined by the Guava personal cell analyser (Guava Technologies Inc., Hayward, CA, USA). Subjects were classified to have normal or abnormal values of lactate based on the reference interval (0.3–2.2 mmol/L). A p value ⩽0.05 was considered statistically significant. s: l of 225 HIV-infected individuals (HAART experienced 213 (95%) and HAART naïve (5%)) were included in the analysis. Mean age was 34 ± 8 and 36 ± 9 years for the individuals with normal and abnormal lactate levels respectively. Of these 185 (82%) had normal (0.3–2.2 mmol/L) and 40 (18%) had abnormal (>2.2 mmol/L) lactate levels. Significant difference in relation to female gender was observed between the normal and abnormal groups (p = 0.03). Among the abnormal group, 39 (97.5%) subjects were HAART experienced compared to 174 (94.1%) normal group. Among the abnormal group, 24 (60%) individuals had a CD4 count of <200 cells/μL as compared to 76 (41.1%) normal subjects. sion: gender should be carefully monitored with respect to their clinical, laboratory and biological data to diminish the occurrence of lactic acidosis.
Keywords :
Resource-limited settings , Female gender , lactate , India , HAART
Journal title :
Food and Chemical Toxicology
Serial Year :
2008
Journal title :
Food and Chemical Toxicology
Record number :
2120243
Link To Document :
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