Title of article :
Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents
Author/Authors :
Rana، نويسنده , , Tanmoy and Bera، نويسنده , , Asit Kumar and Das، نويسنده , , Subhashree and Pan، نويسنده , , Diganta and Bandyopadhyay، نويسنده , , Subhasish and Bhattacharya، نويسنده , , Debasis and De، نويسنده , , Sumanta and Sikdar، نويسنده , , Sourav and Das، نويسنده , , Subrata Kumar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Ascorbic acid is a sugar acid and an essential vital food nutrient found mainly in fruits and vegetables. The purpose of this study was to investigate the effects of ascorbic acid against arsenic induced oxidative stress in blood of rat. In rat, treatment with ascorbic acid prevented the increased serum enzymatic activity of AST, ALT, ALP, ACP and LDH. In addition, treatment with ascorbic acid prevented elevated production of LPO, PC and NO and restored the depletion of reduced SOD and CAT activities. Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-oxidative activity in the blood.
Keywords :
Arsenic , ascorbic acid , oxidative stress , Blood
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
