Author/Authors :
Rogozhin، نويسنده , , Eugene A. and Oshchepkova، نويسنده , , Yulia I. and Odintsova، نويسنده , , Tatyiana I. and Khadeeva، نويسنده , , Natalia V. and Veshkurova، نويسنده , , Olga N. and Egorov، نويسنده , , Tsezi A. and Grishin، نويسنده , , Eugene V. and Salikhov، نويسنده , , Shavkat I. and Netz، نويسنده ,
Abstract :
From seeds of Nigella sativa L. (Ranunculaceae), an endemic plant of Uzbekistan, two novel defensins named Ns-D1 and Ns-D2, were isolated and sequenced. The peptides differ by a single amino acid residue and show high sequence similarity to Raphanus sativus L. defensins Rs-AFP1 and Rs-AFP2. The Ns-D1 and Ns-D2 defensins display strong although divergent antifungal activity towards a number of phytopathogenic fungi. High antifungal activity of N. sativa defensins makes them promising candidates for engineering pathogen-resistant plants.
Keywords :
defensin , antimicrobial peptide , Antibacterial activity , Nigella sativa , antifungal activity
