Title of article :
Kidney and liver distribution of ochratoxin A in male and female F344 rats
Author/Authors :
Vettorazzi، نويسنده , , Ariane and de Trocَniz، نويسنده , , Iٌaki Fernلndez and Gonzلlez-Peٌas، نويسنده , , Elena and Arbillaga، نويسنده , , Leire and Corcuera، نويسنده , , Laura-Ana and Gil، نويسنده , , Ana Gloria and de Cerain، نويسنده , , Adela Lَpez de، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
8
From page :
1935
To page :
1942
Abstract :
The impact of age and gender on Ochratoxin A (OTA) distribution in kidney and liver were studied. OTA was quantified in kidney and liver of young and mature rats of both sexes. Data was fit simultaneously using the population approach with NONMEM program. Fed and fasted mature males showed a 30% decrease and an 11% increase in relative bioavailability, respectively, in comparison with the rest of the groups. The OTA concentrations reached in kidney and liver were very similar between both organs. The models that best fit to data were the ones that considered that distribution of OTA to kidney and liver occurs from the central compartment and that elimination occurs mainly from the liver compartment. The kinetic analysis revealed that both, the apparent volume of distribution of the central compartment (V/F) and the apparent volume of distribution of the liver and kidney compartments (VL,K/F) increased significantly with body weight. Thus, the sex differences observed in organs distribution are a reflection of the differences in relative bioavailability observed in adult males, as a consequence of the fed and fasted conditions and to the significant higher body weight of mature males which directly affected the V/F and VL,K/F.
Keywords :
Ochratoxin A , Population kinetic analysis , Liver , Male and female F344 rat , Kidney
Journal title :
Food and Chemical Toxicology
Serial Year :
2011
Journal title :
Food and Chemical Toxicology
Record number :
2122948
Link To Document :
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