Author/Authors :
Tajkey، Javad نويسنده Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. , , Biglari، Alireza نويسنده Department of Molecular Medicine & Genetics, School of Medicine, Zanjan University of Medical Sciences , , Habibi Asl، Bohlol نويسنده Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. , , Ramazani، Ali نويسنده Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. , , Mazloomzadeh، Saeideh نويسنده Associate Professor, Epidemiologist, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. ,
Abstract :
Purpose: Comparison between the efficacy of ceftriaxone and monocytes on improvement of
neuron protection and functional recovery after spinal cord injury (SCI) in rat.
Methods: Rats were randomly divided into three groups of ten. Spinal cord injury was
performed on rats under general anesthesia using the weight dropping method. Ceftriaxone was
injected intraperitoneally 200 mg/kg/day for seven days after SCI. Monocytes were injected 2 ×
105 cells 4 days after SCI. Hind limb motor function was assessed using the Basso, Beattie and
Bresnahan (BBB) scale. Corticospinal tract (CST) axons were traced by injection of biotin
dextran amine (BDA) into the sensorimotor cortex.
Results: There were statistically significant differences in BBB scores in ceftriaxone in
comparison to both monocytes receiving and control groups. On the other hand there were
statistically significant differences in axon counting in both ceftriaxone and monocytes
receiving groups in comparison to control group.
Conclusion: Our findings suggest that ceftriaxone improves functional recovery more effective
than monocytes in rats after SCI. These results are from an experimental model and validation is
required for further investigation.
