Author/Authors :
Moradzadeh Khiavi، Monir نويسنده Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, International campus, Tehran, Iran. , , Rostami، Ahamd نويسنده Department of Oral and Maxillofacial Pathology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. , , Hamishekar، Hamed نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Mesgari Abassi، Mehran نويسنده , , Aghbali، Amirala نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Salehi، Roya نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Abdollahi، Bita نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Fotoohi، Soheila نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Sina، Mahmud نويسنده Department of Oral and Maxillofacial Pathology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. ,
Abstract :
Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell
carcinoma makes up about 94% of oral malignancies. The aim of the present study was to
compare the efficacy of doxorubicin plus methotrexate - loaded nanoparticles on tongue
squamous cell carcinoma induced by 4NQO and compare it with the commercial
doxorubicin and methotrexate delivered orally on seventy SD male rats.
Methods: 70 rats were divided into five groups. During the study, the animals were weighed
by a digital scale once a week. Number of mortalities was recorded in the data collection
forms. At the end of the treatment, biopsy samples were taken from rat tongues in order to
evaluate the severity of dysplasia and the extent of cell proliferation. The results were
analyzed using ANOVA, descriptive statistics and chi-square test.
Results: No statistically significant difference was found in the mean weight of five groups
(p > 0.05). No significant relationship was found between groups and mortality rate (P = 0.
39). In addition, there was a significant relationship between groups and the degree of
dysplasia (P < 0.001). The statistical analysis showed a significant relationship between
groups and the rate of cell proliferation (p < 0.001).
Conclusion: The results of the present study showed that the use of doxorubicin plus
methotrexate - loaded nanoparticles orally had more therapeutic effects than commercial
doxorubicin plus methotrexate.
