Author/Authors :
Naderi، Roya نويسنده Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. , , Mohaddes، Gisou نويسنده Department of Physiology, Tabriz University of Medical Sciences, Tabriz, IR Iran , , Mohammadi، Mustafa نويسنده Department of Physiology, Medical Faculty, Tabriz University of Medical Sciences, Tabriz-Iran , , Ghaznavi، Rana نويسنده Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. , , Ghyasi، Rafigheh نويسنده Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. , , Vatankhah، Amir-Mansour نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract :
Purpose: Oxidative stress plays a key role in the onset and development of diabetes
complications. In this study, we evaluated whether voluntary exercise could alleviate
oxidative stress in the heart and blood of streptozotocin - induced diabetic rats.
Methods: 28 male Wistar rats were randomly divided into four groups (n=7): control,
exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of
streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running
wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were
collected and used for determination of antioxidant enzymes (including SOD, GPX and
CAT activities) and MDA level.
Results: Exercise significantly reduced MDA levels both in the heart tissue (p < 0.01) and
blood samples (p < 0.05). In addition, exercise significantly increased SOD (p < 0.05), GPX
(p < 0.001) and CAT (p < 0.05) in the heart tissue. Voluntary exercise also significantly
increased SOD (p < 0.01), GPX (p < 0.05) and CAT (p < 0.001) in the blood.
Conclusion: Voluntary exercise diminishes the MDA level in blood and heart tissue of
diabetic rats. It also accentuates activities of SOD, GPX and CAT. Therefore, it may be
considered a useful tool for the reduction of oxidative stress in diabetes.
