Title of article :
Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats
Author/Authors :
Naqshbandi، نويسنده , , Ashreeb and Khan، نويسنده , , Md. Wasim and Rizwan، نويسنده , , Sana and Rehman، نويسنده , , Sayeed ur and Khan، نويسنده , , Farah، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
9
From page :
265
To page :
273
Abstract :
Cisplatin (CP) is a major antineoplastic drug for the treatment of solid tumors, however, dose dependent nephrotoxicity remains the major concern for its long term use. Several agents/strategies were attempted to prevent CP nephrotoxicity but were not found suitable for clinical practice. Dietary fish oil (FO) enriched in ω-3 fatty acids has been shown to prevent/reduce the progression of certain types of cancers, cardiovascular and renal disorders. The present study was undertaken to see whether FO can prevent CP-induced nephrotoxic and other deleterious effects. Rats were prefed experimental diets for 10 days and then received a single dose of CP (6 mg/kg body weight) intraperitoneally while still on diet. Serum/urine parameters, enzymes of carbohydrate metabolism, brush border membrane (BBM) and oxidative stress in rat kidney were analyzed. CP nephrotoxicity was recorded by increased serum creatinine and blood urea nitrogen. CP decreased the activities of metabolic enzymes, antioxidant defense system and BBM enzymes. In contrast, FO alone increased enzyme activities of carbohydrate metabolism and brush border membrane (BBM). FO feeding to CP treated rats markedly enhanced resistance to CP-elicited deleterious effects. Dietary FO supplementation ameliorated CP induced specific metabolic alterations and oxidative damage due to its intrinsic biochemical antioxidant properties.
Keywords :
Nephrotoxicity , Cisplatin , fish oil , Brush border enzymes , Carbohydrate metabolism , oxidative stress
Journal title :
Food and Chemical Toxicology
Serial Year :
2012
Journal title :
Food and Chemical Toxicology
Record number :
2123345
Link To Document :
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