Title of article
Can the L5178Y Tk+/− mouse lymphoma assay detect epigenetic silencing?
Author/Authors
Cheng، نويسنده , , Tsu-Fan and Patton، نويسنده , , Geoffrey W. and Muldoon-Jacobs، نويسنده , , Kristi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
4
From page
187
To page
190
Abstract
The mouse lymphoma L5178Y Tk+/− assay is broadly used in toxicology to assess genotoxicity because of its known sensitivity to genotoxicants that act through a variety of mechanisms, which may include epigenetic DNA methylation. This brief article highlights the studies that have contributed to this conjecture and suggests an addition to the experimental design that could identify if the test substance is a potential epimutagen acting via hypermethylation.
Keywords
TK L5178Y , genetic toxicology , Mouse lymphoma assay , Epigenetics , DNA methylation
Journal title
Food and Chemical Toxicology
Serial Year
2013
Journal title
Food and Chemical Toxicology
Record number
2125621
Link To Document