Distribution of ACE insertion/deletion (I/D) polymorphism in Iranian populations

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Angiotensin converting enzyme (ACE; OMIM: 106180) has an important role in the conversion of angiotensin I to angiotensin II and degradation of bradykinin. Genetic polymorphism I/D (rs4646994) in the gene encoding ACE has been well defined. To get more insight into the genetic structure of Iranian populations, the distribution of the ACE I/D polymorphism among Iranians was compared with each other and with other populations. Prevalence of the D allele was 0.5886 (95% CI: 0.5725-0.6047) in Iran. There was significant difference between Iranian populations (Chi2=27.7, df=6, P2=10.15, df=5, P=0.071). The D allele showed high frequency in Iran which is similar to Caucasians.