Educational Case: Pseudomonas and Acinetobacter Sepsis Due to Thermal Injury

Multi drug resistant (MDR) Pseudomonas and Acinetobacter species are defined as resistant to at least three classes of antibiotics. Most studies have demonstrated that MDR gram negative infections convey increased mortality and morbidity. An 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (TBSA). Role of systemic antibiotics is adjunctive and never replaces surgical debridement, use of topical agents, nutritional support, increasing in immune system function and grafting. Evidence in the published literature suggests that combination therapy with Meropenem and Colistin are effective for burned patients with MDR gram negative sepsis.