Author/Authors :
Hajipour، Abdol Reza نويسنده Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532 WI, USA. , , Sheikhan، Nafisehsadat نويسنده , , Alaei، M. Ali نويسنده Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran , , Zarei، Amin نويسنده ,
Abstract :
A mild and efficient method has been developed for the preparation of substituted coumarins from reaction of various phenols with different B-ketoesters via Pechmann condensation in the presence of Br?nsted acidic ionic liquid (N-(4-sulfonic acid) butyl triethylammonium hydrogen sulfate) as an effective catalyst under solvent-free conditions. Different phenols reacted with ethyl acetoacetate to produce the corresponding substituted coumarins in high to excellent yields and short reaction times. Moreover, [TEBSA][HSO4] has been used as an effective green catalyst for the synthesis of coumarin derivatives under solvent-free conditions. Using the relatively non-toxic (halogen-free) and reusable Br?nsted acidic ionic liquid, high catalytic efficiency, high yields, short reaction times and straightforward work-up are advantages of this protocol.
