Title of article :
The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
Author/Authors :
-، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Eftekharzadeh, Mina , -، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Nobakht, Maliheh , -، - نويسنده Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Alizadeh, Akram , -، - نويسنده Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Medical Genetics and Molecular Biology, Iran Soleimani, Mansooreh , -، - نويسنده Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Hajghasem, Mahmood , -، - نويسنده Department of Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Kordestani Shargh, Bahareh , -، - نويسنده Eposcience Millennium Institute, Tehran, Iran Karkuki Osguei, Nushin , -، - نويسنده Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences, Tehran, Iran Behnam, Babak , -، - نويسنده Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Samadikuchaksaraei, Ali
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2015
Pages :
6
From page :
520
To page :
525
Abstract :
-
Abstract :
Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimerʹs disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment ofAlzheimer’s disease in rat model.
Journal title :
Iranian Journal of Basic Medical Sciences
Serial Year :
2015
Journal title :
Iranian Journal of Basic Medical Sciences
Record number :
2160436
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2160436
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