Author/Authors :
Dehdashtian، Masoud نويسنده Pediatrician, Associate Professor, Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , , Aramesh، Mohammadreza نويسنده Section of Neonatology, Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Malakian، Arash نويسنده Assistant professor of Pediatrics, Department of Neonatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , , Aletayeb، Seyed Mohammad Hassan نويسنده Department of Pediatrics, Abouzar Childrens Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Salehi، Zahra نويسنده Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran ,
Abstract :
Introduction: The elevated Mean Corpuscular Hemoglobin Concentration (MCHC) were reported in neonates with hereditary spherocytosis.
Aims: The aim of this study was to assess the reliability of elevated MCHC as a screening test for the diagnosis of hereditary spherocytosis in newborns.
Methods and Material: We revised records of 1301 neonates with diagnosis of severe hyperbilirubinemia from September 23, 2009 to September 22, 2011. The cases with MCHC ? 36g% were selected. Osmotic fragility test and cell blood counts were per-formed for cases that were enrolled in the study.
Statistical analysis used: Statistical analyses were performed using Statistical Package for Social Sciences, version 15.0 (SPSS, Inc., Chicago, IL, USA). Chi-square test and T-correlation analysis were used for statistical analysis
Results: Out of a total 1301neonates with severe hyperbilirubinemia, 59 of them had MCHC ? 36 g%. Fifty two of 59 selected neonates were finally studied. All of them had MCHC ? 35.7g% and a normal osmotic fragility test.
Conclusions: Elevated MCHC is not a reliable screening test for the diagnosis of he-reditary spherocytosis in neonates with severe hyperbilirubinemia or anemia.
