Author/Authors :
Vojdani، Reza نويسنده Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Geramizadeh، Bita نويسنده , , Mohammadkarimi، Vahid نويسنده Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Talei، Abdolrasoul نويسنده , , Rezvani، AliReza نويسنده , , Dorniani، Gita نويسنده Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Safaei، Akbar نويسنده Department of Pathology, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Ahsant، Samaneh نويسنده Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Piran، Azadeh نويسنده Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Tahmasebi، Sedighe نويسنده Department of Surgical Oncology, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract :
Background: Breast cancer is the most common cause of cancer in women. This tumor
is hormone dependent tumor and oncologists use estrogen receptor (ER), progesterone
receptor (PR) and HER2 for treatment of this malignancy. Androgens like testosterone and
their receptors (AR) have a role in the pathophysiology of breast cancer but their clinical values
are not clear.
Method: AR expression was evaluated in 49 patients with breast cancers using immunohistochemistry.
Testosterone was evaluated with ELISA. The relation of clinical characteristics
and biomarkers with AR and testosterone were analyzed. According to the percentage of stained
cells AR categorized to: AR-absent (0%), AR-poorly (1%-10%), AR-moderately ( > 10%-50%),
and AR-highly ( > 50%) positive.
Results: Among 49 patients with breast cancer, 34% were AR-positive and 44% of ERpositive
and 22% of ER negative patients were AR-positive. There was no significant
association between mean of testosterone and AR, ER, PR and HER2. AR was positive more
frequently but not significantly statistically in older patients and patients less than 45 years of
age. Testosterone level was higher in ER positive patients than ER negative and lower in AR
positive patients than AR negative patients, but these findings were not statistically significant.
ten persent of breast cancers were triple negative and AR was negative in all of them.
Conclusion: Androgens and AR have role in pathophysiology of breast cancer and in the
future one can use the potency of this pathway for the treatment of breast cancer.
