Title of article
Effect of Quercetin on RAC1 Gene Expression as a Marker of Metastasis in Cervical Cancer Cells
Author/Authors
Chakerzehi، Arezu نويسنده Department of Medical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, IR Iran Chakerzehi, Arezu , Eivazi Arvanagh، Neda نويسنده Department of Medical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, IR Iran Eivazi Arvanagh, Neda , Saedi، Samaneh نويسنده Department of Laboratory Sciences, Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IR Iran Saedi, Samaneh , Hematti، Mahdiyeh نويسنده Department of Medical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, IR Iran Hematti, Mahdiyeh , Mohiti-Ardakani، Javad نويسنده Department of Biochemistry and Molecular Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Moradi، Ali نويسنده Department of Medical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, IR Iran Moradi, Ali , Shokouhi، Abolfazl نويسنده Department of Medical Biochemistry, Shahid Sadughi University of Medical Sciences, Yazd, IR Iran Shokouhi, Abolfazl
Issue Information
ماهنامه با شماره پیاپی 0 سال 2015
Pages
5
From page
1
To page
5
Abstract
Background: Cancer metastasis is the most important cause of cancer death and different treatment strategies have targeted on preventing the occurrence of metastasis. Quercetin is a flavonoid and widely used as an antioxidant and recent studies have discovered its anticancer and antiproliferative capabilities. Rac1 is protein known to involve in tumor invasion and metastases.
Objectives: In this study, we investigated the effect of quercetin on expression of Rac1 protein.
Materials and Methods: In this experimental study, HeLa cells were treated with quercetin at 2 concentrations (20 and 40 ?M) for 24 hours and then cell lysate was assessed by Western blotting analysis to investigate the impact of quercetin on expression of Rac1 protein.
Results: Quercetin significantly decreased Rac1 expression of HeLa cells assessed by western blotting, in dose-dependent manners (P < 0.05).
Conclusions: This study showed that quercetin decreased Rac1 expression as a marker of metastasis in cervical cancer cells. Therefore, the quercetin may provide an effective new strategy to reduce of tumor metastasis.
Journal title
Zahedan Journal of Research in Medical Sciences
Serial Year
2015
Journal title
Zahedan Journal of Research in Medical Sciences
Record number
2178551
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