Author/Authors :
Gozukara، Ilay Ozturk نويسنده Department of Obstetric and Gynecology, Dumlup?nar University Medical Faculty Hospital , Kütahya, Turkey , , Gozukara، Kerem Han نويسنده Department of Urology, Paland?ken Hospital, Erzurum, Turkey , , Kucur، Suna Kabil نويسنده Department of Obstetric and Gynecology, Dumlup?nar University Medical Faculty Hospital , Kütahya, Turkey , , Karak?l?c، Eda Ulku نويسنده Department of Obstetric and Gynecology, Nenehatun Women Health Hospital, Erzurum, Turkey , , Keskin، Havva نويسنده Department of Internal Medicine, Erzurum B?lge Training and Research Hospital, Erzurum, Turkey , , Akdeniz، Derya نويسنده Department of Internal Medicine, Fatih University Medical Faculty Hospital, Ankara, Turkey , , Aksoy، Ayse Nur نويسنده Department of Obstetric and Gynecology, Nenehatun Women Health Hospital, Erzurum, Turkey , , Carl?oglu، Ayse نويسنده Department of Internal Medicine, Erzurum B?lge Training and Research Hospital, Erzurum, Turkey ,
Abstract :
Background: We aimed to estimate the glomerular filtration rate (GFR) in women with
polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with
C-reactive protein (CRP) and uric acid.
Materials and Methods: In this cross-sectional study, one-hundred and forty PCOS
women and 60 healthy subjects were evaluated. The study was carried out at Endocrinology
Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from
December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal
Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels
were also measured.
Results: GFRs were significantly higher in PCOS group than control (135.24 ±
25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher
in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly
higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also
significantly higher proteinuria level in PCOS patients.
Conclusion: Even though PCOS patients had higher GFR, serum uric acid and UAE values
than control patients, the renal function was within normal limits. Increased GFR in
PCOS women positively correlates with elevated serum CRP and uric acid.
