Author/Authors :
Starkoff، Brooke E. نويسنده Department of Kinesiology, Sport Studies, and Exercise Science The College at Brockport, SUNY350 New Campus Drive, Brockport, NY 14420, USA , , Eneli، Ihuoma U. نويسنده Nationwide Children’s Hospital 700 Children’s Dr., Columbus, OH 43205 , , Bonny، Andrea E. نويسنده Nationwide Children’s Hospital 700 Children’s Dr., Columbus, OH 43205 , , Hoffman، Robert P. نويسنده Nationwide Children’s Hospital 700 Children’s Dr., Columbus, OH 43205 , , Devor، Steven T. نويسنده Department of Human Sciences – Kinesiology Program, The Ohio State University A50 PAES Building, 305 West 17th Ave., Columbus, OH 43210 ,
Abstract :
Inactivity combined with obesity during adolescence increases the risk of future cardiovascular disease. The study
purpose was to compare the influence of differing intensities of exercise on endothelial function in sedentary
adolescents with obesity. Participants were randomized to one of two groups in a 6-week exercise intervention:
moderate intensity (MOD) or high intensity interval exercise (HIIE). Endothelial function was assessed pre- and postintervention
via fasted serum levels of endothelin-1 (ET-1). Pre-measures of ET-1 concentrations were elevated at
baseline. No significant differences in ET-1 were found between or within exercise groups. However, in the HIIE
group, ET-1 was inversely associated with percentages of age predicted maximal heart rate achieved during the
intervention (p=0.035, r=-0.567). The exercise interventions did not positively change ET-1 levels, yet participants who
exercised at higher intensities in the HIIE group experienced greater decreases in ET-1.
