Study on sonodynamic activity of metallophthalocyanine sonosensitizers based on the sonochemiluminescence of MCLA

In this work, the chemiluminescence analysis method was used to detect the free radical during sonodynamic process. MCLA, which can specifically react with singlet oxygen (1O2) or superoxide anion to emit photon, was used to detect free radical formation in the sonosensitization of metallophthalocyanine in real time. The ultrasound-induced chemiluminescence of MCLA enhanced by sulfonated phthalocyanines Nickel did not show the expected structure–activity relationship which was well known as type II mechanism for the photodynamic therapy related to singlet oxygen production. The results showed that free radical are involved in the sonosensitization, and the catalytic performance of NiPcS4 was the main reason for the increase of SCL.