Author/Authors :
Pattar، Vijay P نويسنده P. G. Department of studies in Chemistry, Karnatak University, Dharwad - 580003, India Pattar, Vijay P , Bagoji، Atmanand M نويسنده P. G. Department of studies in Chemistry, Karnatak University, Dharwad - 580003, India Bagoji, Atmanand M , Gokavi، Naveen M نويسنده P. G. Department of studies in Chemistry, Karnatak University, Dharwad - 580003, India Gokavi, Naveen M , NANDIBEWOOR، SHARANAPPA.T. نويسنده ,
Abstract :
In this study, the electrochemical
behaviour
of 2
-
thiouracil (2TU) has been
investigated
using cyclic, differential pulse and square wave voltammetric techniques.
The
electrochemical studies were carried out in pH 3 with 0.2
M phosphate buffer as supporting
electrolyte. Cyclic voltammetric studies w
ere performed in a wide range of sweep rates and
various concentrations of 2TU.
The effect of surfactants was studied.
The anodic peak was
characterized and proc
ess was adsorption
-
controlled.
According to the linear relation between
the peak current and th
e 2TU concentration, differential
-
pulse voltammetric method for the
quantitative determination in pharmaceuticals was developed. The linear response was
obtained in the range of 1
–
11 ?M with a detection limit of 2.05
×
10
-
8
M with good selectivity
and sensit
ivity. The proposed method was successfully applied to 2TU determination in
pharmaceutical samples and for the detection of 2TU in urine as a real sample
