Author/Authors :
Derakhshanrad، Nazi نويسنده Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Derakhshanrad, Nazi , Saberi، Hooshang نويسنده Brain and Spinal Cord Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Keshavarz Blvd., Tehran, Iran. Saberi, Hooshang , Tayebi Meybodi، Keyvan نويسنده Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Tayebi Meybodi, Keyvan , Taghvaei، Mohammad نويسنده Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Taghvaei, Mohammad , Arjmand، Babak نويسنده Brain and Spinal Injury Research Center, Tehran University of Medical Sciences , , Aghayan، Hamid Reza نويسنده Brain and Spinal Injury Research Center, Tehran University of Medical Sciences , , Kohan، Amir Hassan نويسنده Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Kohan, Amir Hassan , Haghpanahi، Mohammad نويسنده School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran , , Rahmani، Shahrokh نويسنده Department of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran Rahmani, Shahrokh
Abstract :
Introduction: Various neuroregenerative procedures have been recently employed along with
neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI),
and recently most of them have focused on the acute stage of spinal cord injury. In this report,
we present a case of acute SCI treated with neuroprotective treatments in conjunction with
conventional rehabilitation program.
Methods: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with
intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating
Factor (G-CSF) along with rehabilitation program. The neurological outcomes as well as safety
issues have been reported. Results: Assessment with American Spinal Injury Association (ASIA), showed neurological
improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication. Discussion: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal
Stem Cells (MSCs) was safe in our case as an adjunct to conventional rehabilitation programs.
Further controlled studies are needed to find possible side effects, and establish net efficacy.
