Author/Authors :
Jamshidzadeh، Akram نويسنده , , Mardani، Zeinab نويسنده School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Ghahramani، Leila نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Mohammadi، Soleiman نويسنده School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Seyed Raoufi، Seyed Mojtaba نويسنده School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Safarpour، Alireza نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Izadpanah، Ahmad نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Hosseini، Seyed Vahid نويسنده , , Rahimi، Masoumeh نويسنده M.A. in Teaching English as a Foreign Language (TEFL), Iran ,
Abstract :
Anal fissure is a painful tear or crack in the distal part of anal canal. It usually involves the epithelium, but in the long term it may extend to the whole anal mucosa. Platelet Lysate (PL) hydrogel is a hemoderivitive pharmaceutical formulation that contains plenty of growth factors. These growth factors can induce tissue regeneration and revascularization as well as fibroblast proliferation. This study aimed to evaluate the effectiveness of PL hydrogel in the treatment of the anal fissure or retardation of its development. The patients with chronic and acute anal fissure were randomly divided into groups of A and B. Group A received PL hydrogel and Rectol, while group B received placebo and Rectol. Then, they were followed and evaluated for two weeks. Although it was anticipated that platelet growth factors would be effective in anal fissure healing process, no significant difference was observed between the control group and the case group after the treatment. Nevertheless, a significant difference was observed within the two groups after the treatment. PL hydrogel does not seem to have beneficial effects compared to the placebo or Rectol on the healing of anal fissure.
