Author/Authors :
Nikkhah، Ali نويسنده MD,Pediatric Neurologist, Department of Pediatric Neurology, Children´s Medical Center, Tehran University of Medical Sciences, Tehran, Iran , , Ghahremanitamadon، Fatemeh نويسنده Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran , , Zargooshnia، Somayeh نويسنده Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran , , Shahidi، Siamak نويسنده , , Soleimani Asl، Sara نويسنده Department of Anatomical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract :
Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task. The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats.
