Author/Authors :
Arbabi-Kalati، Fateme نويسنده Department of Oral Medicine, Genetics of Non Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Za Arbabi-Kalati, Fateme , Nosratzehi، Tahereh نويسنده Department of Oral Medicine, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran Nosratzehi, Tahereh , Bameri، Zakaria نويسنده Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Bameri, Zakaria , Rigi، Fiz Mohammad نويسنده Department of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran ,
Abstract :
Human papilloma virus (HPV) infection of the oropharynx is acquired through a variety of sexual and social forms of transmission. Recent epidemiologic evidence has suggested that HPV may be an independent risk factor for oropharyngeal cancers, but risk factors for persistent HPV infection in the oropharynx are unknown. More evidence is needed regarding the prevalence of oral high-risk HPV among healthy smoker and nonsmoker adults. The aim of this study was to compare salivary infection with human papilloma virus types 16 and 18 between smokers and nonsmokers. A hundred healthy adult subjects were selected from Zahedan dental school for this pilot study. DNA was isolated from saliva samples and screened for high-risk HPV strains of HPV 16 and 18. Then, further processed using Real Time PCR for quantification and confirmation of sensitivity and specificity of the test. Data was analyzed by t-test. There were no high-risk types of virus in patients and no significant differences between the groups (P = 1). It seems that smoking cannot increase the prevalence of high risk HPV 16, 18 in saliva samples.
