Author/Authors :
Shahraki، Shahram نويسنده Department of Microbiology, Zahedan University of Medical Sciences, Zahedan, Iran Shahraki, Shahram , Mohammadzadeh-Rostami، Farzaneh نويسنده 2Department of Microbiology, Zahedan University of Medical Sciences, Zahedan, IR Iran Mohammadzadeh-Rostami, Farzaneh , Haddadi-Feishani، Mehdi نويسنده 2Department of Microbiology, Zahedan University of Medical Sciences, Zahedan, IR Iran Haddadi-Feishani, Mehdi , Mohagheghifard، Amir Hossein نويسنده 3Department of Virology, Zahedan University of Medical Sciences, Zahedan, IR Iran Mohagheghifard, Amir Hossein , Jahani Sherafat، Somayeh نويسنده Taleghani Hospital, Internal Medicine Department, Shahid Beheshti University of Medical Sciences , , Majidiani، Hamidreza نويسنده 4Candidate of Veterinary Medicine, Faculty of Veterinary, Zabol University, Zabol, IR Iran Majidiani, Hamidreza
Abstract :
Background: Klebsiella pneumoniae is among the most common and significant agents of community and hospital-acquired infections. Plasmid-mediated quinolone resistance (PMQR) was increasingly identified in Enterobacteriaceae family worldwide. Quinolones are broad-spectrum antibiotics the resistant to which has increasingly been reported among many bacterial species including Klebsiella. The current study was conducted to evaluate the prevalence of quinolone-resistant strains of K. pneumoniae in Zahedan during 2013 and 2014.
Materials and Methods: In this cross-sectional study, 184 samples of K. pneumoniae were collected. Isolates were screened for quinolone antibiotics resistance using disk diffusion method according to clinical and laboratory standards institute (CLSI) guidelines. Also MIC (minimum inhibitory concentration) was used against the ciprofloxacin antibiotic by the dilution method in tubes.
Results: Based on the obtained results by the Agar disk diffusion test, 31.5%, 18.4%, 17.3%, 4.3%, 3.2% and 2.1% of the strains were resistant to nalidixic acid, ciprofloxacin, norfloxacin, ofloxacin, levofloxacin, and getifloxacin respectively.
Conclusions: Our results show increased prevalence of quinolone resistance among K. pneumoniae in south-east of Iran. This may stem from their irrational prescription thus it is recommended that their prescription be based on antibiotic sensitivity test results. We also recommend further evaluation using molecular techniques and also preventive measures.
