Author/Authors :
Doosti Irani، Amin نويسنده Department of Epidemiology & Biostatistics, School of Public Heath, Hamedan University of Medical Sciences, Hamedan, Iran , , Cheraghi، Zahra نويسنده Department of Epidemiology & Biostatistics, School of Public Heath, Hamedan University of Medical Sciences, Hamedan, Iran , , Bitaraf، Saied نويسنده 2General Physician, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran Bitaraf, Saied , Cheraghi، Parvin نويسنده Department of Public Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , , Safiri، Saeid نويسنده Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran Safiri, Saeid
Abstract :
Background: We aimed to investigate the alpha and beta-thalassemia mutations and assess the association of hematologic indices with mutations.
Patients and Methods: In this cross sectional study, we assessed 275 suspected thalassemia carriers. Amplification refractory mutation system-polymerase chain reaction and Gap PCR were used for detection of mutations.
Results: CD 36 - 37 (-T) and -?3.7/?? were most common mutations. Mean of corpuscular hemoglobin and corpuscular volume was less among beta-thalassemia carriers in comparison to alpha-thalassemia carriers (P = 0.001).
Conclusions: Detected mutations were different from other regions in Iran. After iron therapy, mean of corpuscular volume (MCV) was < 69 fL and mean of corpuscular hemoglobin was < 23 pg, may be classified as beta-thalassemia carriers.
