Title of article
Ulcerative Colitis and Limb Loss: A Case Report
Author/Authors
Ghahramani، Leila نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Rezaianzadeh، Abbas نويسنده Department of Epidemiology, Cardiovascular Research Center, Shiraz University of Medical Science , , Moslemi، Sam نويسنده Department of General Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Rahimikazerouni، Salar نويسنده Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Hosseini، Seyed Vahid نويسنده ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2014
Pages
1
From page
0
To page
0
Abstract
Protein C is a precursor of a vitamin K-dependent serine protease, which is activated by thrombin in the presence of endothelial cofactor, thrombomodulin and endothelial cell protein C receptor. A 33-year old woman with acute exacerbation of ulcerative colitis was found to have protein C deficiency (serum protein C activity estimated as 35% of the normal activity). Protein C deficiency was diagnosed after the onset of several arterial thromboemboli complications (brachiocephalic and popliteal artery thrombosis) during her hospital admission for exacerbation of ulcerative colitis (UC). Therefore, upper limb below elbow and lower limb below knee amputation were performed for her. After total proctocolectomy, serum protein C activity remained as 35% of the normal activity, so the patient used warfarin as lifelong anticoagulant. Investigation of other family members revealed normal thrombophilia screening tests.
Journal title
Scimetr: An International Journal of Medical Sciences
Serial Year
2014
Journal title
Scimetr: An International Journal of Medical Sciences
Record number
2235783
Link To Document