Reaction time slowing in adults with HIV: Results of a meta-analysis using brinley plots

A meta-analysis in the form of Brinley plots was conducted on the mean reaction times of HIV+ and HIV− groups. HIV+ reaction times were regressed on HIV− reaction times across 122 task conditions from 29 studies, producing a highly linear function (r2=.94), with a slope b=1.039, which was not significantly different than b=1.00. Asymptomatic and symptomatic HIV+ reaction times were also separately regressed on HIV− reaction times across 67 task conditions from 13 studies. Both functions were highly linear (r2=.97 and .90 respectively), with slopes of 1.034 and 1.117 respectively. Only the slope for symptomatic HIV+ groups was significantly larger than b=1.00, suggesting a modest generalized slowing of cognition in these adults.