Author/Authors :
Haghighat، Mahmood نويسنده Department of Pediatrics Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran , , Shahramian، Iraj نويسنده Pediatricians, Zahedan, Iran Shahramian, Iraj , Imanieh، Mohammad Hadi نويسنده Gastroenterohepatology Research Center, Department of Pediatric Gastroenterology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Ir , , DEHGHANI، SEYED MOHSEN نويسنده Gastroenterohepatology Research Center, Shiraz Transplant Research Center, Nemazee Teaching Hospital, Medical School, Shiraz University of Medical Sci , , Teimouri، Alireza نويسنده Neurosurgery Department, Faculty of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Noori، Noor Mohammad نويسنده Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan, Iran. ,
Abstract :
Aim: This study aimed to evaluate the erythromycin efficacy in childhood cyclic vomiting syndrome.
Background: Cyclic vomiting syndrome (CVS) is an unusual cause of episodic emesis in children and erythromycin is an effective treatment.
Patients and methods: In this prospective study, 301 patients with a final diagnosis of CVS enrolled in two separated groups. The first group received erythromycin for 7 days and propranolol for at least 9 months (n=155). The second group was treated with propranolol alone for at least 9 months (n=146). These two groups were compared for response to the treatment and the recurrence of symptoms after treatment completion. Relationship of response, recurrence, and characteristics of the disease was assessed.
Results: Both groups showed a significant difference in terms of response to treatment (P=0.002), however the recurrence after treatment completion had no considerable difference (P=0.563). There was no relationship between CVS characteristics and these two items (response and recurrence).
Conclusion: In our point of view, the addition of erythromycin to standard propranolol treatment can improve the response to treatment, although it has no significant effect on recurrence of CVS symptoms. We suggest the use of erythromycin for 7 days in addition to CVS standard therapy.
