Title of article
Induction of CYP1A and ABC transporters in European sea bass (Dicentrarchus labrax) upon 2,3,7,8-TCDD waterborne exposure
Author/Authors
Della Torre، نويسنده , , Camilla and Mariottini، نويسنده , , Michela and Vannuccini، نويسنده , , Maria Luisa and Trisciani، نويسنده , , Anna and Marchi، نويسنده , , Davide and Corsi، نويسنده , , Ilaria، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
5
From page
218
To page
222
Abstract
The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg/L) for 24 h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24 h and 7 d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass.
Keywords
TCDD , ABC transport proteins , CYP1A , European sea bass , Detoxification
Journal title
Marine Environmental Research
Serial Year
2014
Journal title
Marine Environmental Research
Record number
2256726
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