Author/Authors :
Assaei، Raheleh نويسنده Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran Assaei, Raheleh , Mostafavi-Pour، Zohreh نويسنده Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; , , Pajouhi، Naser نويسنده Department of Physiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Pajouhi, Naser , Ranjbar Omrani، Gholam Hossein نويسنده Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Sepehrimanesh، Masood نويسنده Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran , , Zal، Fatemeh نويسنده ,
Abstract :
This work analyzes the effects of Satureja khuzestanica essential oil (SKEO) on the thyroid and antioxidant system, assessed by measuring levels of tri-iodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), reduced glutathione (GSH), and glutathione peroxidase (GPx) activity. Forty adult male Sprague Dawley rats (225 ± 25 g) were divided into five equal groups: one control and four hyperthyroid groups that received placebo, 200 mg kg-1 body weight of vitamin (Vit.) E, 225 mg kg-1 body weight of SKEO, 200 and 225 mg kg-1 body weight of Vit. E and SKEO together, respectively. Hyperthyroidism was induced by administering of L-thyroxin in drinking water. After 30 days of L-thyroxin consumption, serum T3 and T4 levels, TSH, and oxidative stress indices were determined. Significant increase in serum T3, T4 and MDA concentrations with a simultaneous significant decrease in TSH, GSH level and GPx activity were observed in hyperthyroid group (p < 0.05). In the treatment groups, SKEO and/or Vit. E can compensate serum MDA elevation and GPx activity reduction. Only, SKEO + Vit. E could compensate the decline of GSH levels in response to hyperthyroidism. Supplementation of SKEO, plus Vit. E as antioxidants is useful in attenuating lipid peroxidation and may potentially benefit hyperthyroid patients.
