Author/Authors :
SHIARI، Reza نويسنده MD,Ph.D,Assistant Professor of Pediatric Rheumatology,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , HASSASE YEGANE، Mehrnoush نويسنده Department of Paediatric Rheumatology, Shahid Behshti University of Medical Sciences, Mofid Children’s Hospital, Tehran, Iran. , , FARIVAR، Shirin نويسنده Department of Genetics, Faculty of Biological Science, Shahid Beheshti University, GC, Tehran, Iran. , , JAVADI PARVANEH، Vadood نويسنده 2. Fellow of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran-Iran ,
Abstract :
Systemic Lupus Erythematosus (SLE) is an autoimmune, multisystem disorder
with various manifestations. There are limited reports on the neuropsychiatric
findings as the first manifestation of SLE in children. Herein, we report a
14-year-old Iranian boy with a two-year history of cognitive dysfunction and
behavioural problems as well as a recent history of epistaxis. The patient workup
ended with a diagnosis of Klinefelter’s syndrome associated with juvenile
SLE. Patients with Klinefelter’s syndrome may exhibit behavioural problems
and psychological disease. These psychiatric disorders could be complicated
with lupus in children. In fact, psychiatric symptoms may occur as the first
manifestation of juvenile SLE. Specially, if accompanied with Klinefelter’s
syndrome. We suggest the diagnosis of SLE must be considered in all children
with neuropsychiatric manifestations.
