Author/Authors :
Abroun، Saeid نويسنده Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Saki، Najmaldin نويسنده Department of Hematology and Blood Banking School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Ahmadvand، Mohammad نويسنده Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Asghari، Farahnaz نويسنده Department of Medicine II, Division of Gastroenterology, University of Rostock, E.Heydemann-Strasse 6, Rostock, Germany , , Salari، Fatemeh نويسنده Department of Law, Kerman Science and Research Branch, Islamic Azad University, Kerman, Iran , , Rahim، Fakher نويسنده Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
Abstract :
Signal transducers and activators of transcription (STATs) are cytoplasmic transcription
factors that have a key role in cell fate. STATs, a protein family comprised of
seven members, are proteins which are latent cytoplasmic transcription factors that
convey signals from the cell surface to the nucleus through activation by cytokines
and growth factors. The signaling pathways have diverse biological functions that
include roles in cell differentiation, proliferation, development, apoptosis, and inflammation
which place them at the center of a very active area of research. In this review
we explain Janus kinase (JAK)/STAT signaling and focus on STAT3, which is
transient from cytoplasm to nucleus after phosphorylation. This procedure controls
fundamental biological processes by regulating nuclear genes controlling cell proliferation,
survival, and development. In some hematopoietic disorders and cancers,
overexpression and activation of STAT3 result in high proliferation, suppression of
cell differentiation and inhibition of cell maturation. This article focuses on STAT3
and its role in malignancy, in addition to the role of microRNAs (miRNAs) on STAT3
activation in certain cancers.
