Author/Authors :
Yazdanpanah، Mohhamad Javad نويسنده Department of Dermatology, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Sharifi، Norieh نويسنده Department of Pathology, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Khooei، Alireza نويسنده , , Banihashemi، Mahnaz نويسنده Department of Dermatology, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Khajedaluee، Mohammad نويسنده , , Shamsi، Azadeh نويسنده Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran , , Ghazvini، Kiarash نويسنده ,
Abstract :
Background: The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain.
Objectives: We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran.
Patients and Methods: Sixty six patients with morphea were prospectively included in the present study. For each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for Borrelia spp. DNA using PCR.
Results: No Borrelia DNA was detected by PCR in skin lesions of patients with morphea.
Conclusions: The result of this study showed no relationship between Borrelia infection and morphea lesions and in other word indicated that morphea, at least in Iran, is not caused by Borrelia spp.
