Author/Authors :
Mazaheri، Shahram نويسنده Resident of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran , , Sadeghi، Masoumeh نويسنده , , Sarrafzadegan، Nizal نويسنده MD, Professor of Cardiology, Isfahan Cardiovascular Research Center, IUMS, Isfahan , , Sanei، Hamid نويسنده Department of Internal Medicine , , Hekmatnia، Ali نويسنده , , Tavakoli، Babak نويسنده Radiologist, Department of Radiology, Isfahan University of Medical sciences, Isfahan, Iran ,
Abstract :
BACKGROUND: Previous studies reported that the distribution of body fat is an important risk
factor for coronary artery diseases (CAD) and abdominal adipose tissue is associated with severe
CAD. This study was conducted to evaluate the relationship between body fat distributions,
plasma lipids and the severity of CAD in patients with stable angina.
METHODS: Ninety seven patients who underwent coronary angiography for stable angina were
allocated into two groups: patients with mild or sever coronary artery involvement. Lipid profile
(total cholesterol, LDL, HDL) and triglyceride (TG) and apolipoprotein A and B, were measured
for all of the participants and a demographic data questionnaire was filled by the subjects. Participants
underwent abdominal computed tomography (CT-Scan) for measurement of adipose
tissues that was classified to visceral and superficial and deep subcutaneous fat tissue compartment.
RESULTS: Patients with severe coronary artery involvement had higher level of apo B
(P = 0.02). Significant correlation was seen between visceral fat index and TG (P = 0.01), HDL-C
(P < 0.01) in patients with mild coronary involvement and with total cholesterol (P = 0.02),
LDL-C (P = 0.01) and apoB (P < 0.01) in patients with severe coronary involvement .No significant
relationship was seen among deep cutaneous fat index and lipid profile in both groups.
CONCLUSION: Our findings showed that visceral adipose tissue is significantly associated with
severe CAD and has a significant correlation with lipid profile as well as Apo B.
