Author/Authors :
Sedaghat، Akram نويسنده Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Sedaghat, Akram , Sadeghi، Masoumeh نويسنده , , Heidari، Ramin نويسنده Assistant Professor of Cardiology , , Sistani، Efat نويسنده Isfahan University of Medical Science, Isfahan, Iran , , Bayanfar، Zahra نويسنده Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract :
BACKGROUND: Immunopathological and inflammatory processes play important roles in the
initiation and development of ischemic heart disease. Hence, this study aimed to evaluate the
relationship between serum levels rheumatoid factor (RF) and anti-nuclear antibodies (ANA)
and severity of coronary stenotic lesions.
METHODS: Totally 140 patients with acute coronary syndrome (ACS) (n = 70) and chronic
stable angina (CSA) (n = 70) that undergoing coronary angiography were enrolled in this
study. ANA by the enzyme-linked immunosorbent assay (ELISA) and serum level of RF was
measured by latex method. The severity of coronary stenotic lesions calculated by Gensini
score. To analyze the correlations of ANA and RF to Gensini score Pearson correlation test
was used. To adjust the effect of age and other confounder factors such hypertension,
diabetes, hyperlipidemia and smoking multiple linear regression was used.
RESULTS: The mean serum levels of RF and ANA in CSA group were significantly higher than
ACS group after adjusting for the confounder factors (P < 0.050 for ANA). Serum levels of ANA
significantly correlated with severity of coronary stenotic lesions calculated by Gensini score
(r = 0.40 and P < 0.050). After adjusting confounders, multiple linear regression analysis
showed ANA remained independently associated with Gensini scores in ACS group (B = 0.505,
P < 0.001).
CONCLUSION: Higher serum levels of ANA may be considered as independent risk factors for ACS.
