Author/Authors :
Moohebati، Mohsen نويسنده Mashhad University of Medical Sciences , , Yazdandoust، Shima نويسنده Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Sahebkar، Amirhossein نويسنده Mashhad University of Medical Sciences , , Mazidi، Mohsen نويسنده Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. , , Sharghi-Shahri، Zahra نويسنده Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , Ferns، Gordon نويسنده Professor, Brighton and Sussex Medical School, Mayfield House, University of Brighton, Brighton, UK , , Ghayour-Mobarhan، Majid نويسنده MD, PhD, Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science, Mashhad ,
Abstract :
BACKGROUND: Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL
considered to have the most atherogenic properties. The present trial aimed to assess changes in
circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic
compounds with diverse potential cardio-protective functions.
METHODS: This study was designed as a randomized double-blind placebo-controlled crossover
trial. A total of 30 obese dyslipidemic subjects were assigned to curcuminoids (1 g/day) or
placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for
another 4 weeks. Serum sdLDL was measured at baseline and weeks 4, 6, and 10 of the trial.
RESULTS: Supplementation with curcuminoids (1 g/day) did not cause any significant alteration
in serum sdLDL (P > 0.05).
CONCLUSION: Four-week supplementation with curcuminoids was not associated with any
significant alteration in circulating sdLDL concentrations.
