Author/Authors :
KHOSRAVI، ALIREZA نويسنده , , Pourbehi، Mohammad Reza نويسنده The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. , , Pourmoghaddas، Masoud نويسنده MD, Professor of Interventional Cardiology, Chamran Heart Hospital, Isfahan University of Medical Sciences, Isfahan , , Ostovar، Afshin نويسنده Departement of Epidemiology, Persian Gulf Tropical Medicine Research
Center , , Akhbari، Mohammad Reza نويسنده Cardiologist, Isfahan University of Medical Sciences, Isfahan, Iran. , , Ziaee-Bideh، Fereshteh نويسنده Assistant Professor, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran , , Golshahi، Jafar نويسنده Associate Professor, Isfahan Cardiovascular , , Shirani، Shahin نويسنده Associate Professor, Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract :
BACKGROUND: Today, the fractional flow reserve (FFR) guides the physician to select suitable
patients with intermediate severity coronary lesions in angiography that should be treated or
not with stent. The aim of this study was to evaluate the impact of using FFR in the selection of
appropriate treatment strategy in angiographic intermediate coronary lesions and their shortterm
outcome in a sample of Iranian population.
METHODS: In a prospective cohort, 34 patients who had intermediate coronary artery lesion(s),
defined as having a 40-70% diameter stenosis, as determined by visual estimation or
quantitative coronary angiography were enrolled through a convenience sampling method. All
patients underwent FFR measurement to decide whether percutaneous coronary intervention
should be performed. The results of visual assessment, quantitative coronary angiography, and
functional assessment of the severity of coronary stenosis were compared. Significant stenosis
was defined as FFR < 0.80. All patients were followed for 6 months for the incidence of major
advanced cardiac events.
RESULTS: In this study, 34 patients (22 male and 12 female) with mean age of 57 ± 8 (range
45-70) were included. In 26.47% (9/34) of patients, FFR was < 0.80, they underwent coronary
angioplasty. The correlation between visual estimation and quantitative assessment of lesion
diameter was 0.804 (P < 0.001). During the follow-up period, no major advanced cardiac events
were reported. In addition, 5.88 (2/34) of patients had a left main (LM) lesion with FFR > 0.80
and stenting was done to the other vessels with significant coronary lesions.
CONCLUSION: Measurement of FFR is a useful approach in making clinical decisions about
revascularization procedures in patients with moderate coronary artery lesion severity,
especially in LM and multivessel disease. This study showed that not only FFR can change
treatment plan of the patients, but also it would improve clinical outcomes.
