Author/Authors :
Nakhaee، Alireza نويسنده Department of Clinical Biochemistry, Cellular and Molecular Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Nakhaee, Alireza , Hashemi، Mohammad نويسنده Professor, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , , Rezaeifar، Alireza نويسنده Lecturer, Department of Clinical Biochemistry, Zabol University of Medical Sciences, Zabol, Iran , , Kaykhaei، Mahmoud Ali نويسنده Assistant Professor, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran ,
Abstract :
BACKGROUND: Haptoglobin (Hp) polymorphisms have been suggested to be associated with
many pathological conditions, including cardiovascular diseases, infectious diseases, and type 2
diabetes. For the first time, we aimed to investigate the possible association between Hp
genotypes and metabolic syndrome (MES) in a sample of Iranian subjects.
METHODS: In this study, 291 patients with MES according to National Cholesterol Education
Program-Adult Treatment Panel III criteria, and 284 healthy individuals have been studied. We
determined Hp genotype by polymerase chain reaction.
RESULTS: The frequency of three genotype (Hp1-1, Hp2-1, and Hp2-2) in healthy individuals
and patients were 7.74, 39.7, 52.46, and 7.9, 31.61, 60.48 percent, respectively. There was no
significant difference between the groups regarding Hp genotypes. The Hp2 allele was the
predominant allele in MES (76.29%) and normal subjects (72.54%).
CONCLUSION: Hp polymorphisms are not risk factor for predisposition to MES in a sample of the
Iranian population. Further studies with different ethnicities are required to validate our findings.
