Author/Authors :
Mirmohammadsadeghi، Pouya نويسنده Student of Medicine, Isfahan Medical Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran , , Mirmohammadsadeghi، Mohsen نويسنده Department of Cardiac Surgery, Isfahan University of Medical Sciences, Isfahan ,
Abstract :
BACKGROUND: Superior results will be achieved from cardiac surgery by minimizing the effect
of ischemia/reperfusion injury during cross-clamping of the aorta. Different cardioplegia
solutions have been introduced, but the optimum one is still ambiguous. The aim of this study is
to determine the effect of single antegrade hot shot terminal warm blood cardioplegia (TWBC)
on patients who had undergone coronary artery bypass grafting (CABG).
METHODS: In total, 2488 patients who had CABG surgery in Sina Hospital, Isfahan, Iran, from
2003 to 2011 were enrolled in this case-control study. They were divided into two groups, those
who received cold cardioplegia only and those who received a hot shot following cold
cardioplegia. Demographics, and clinical data, such as; premature atrial contraction (PAC)
arrhythmia, diabetes treatment, and left ventricular ejection fraction (EF), were collected and
logistic regression analysis was used to analyze the data.
RESULTS: There were significant differences found between subjects receiving antegrade hot
shot based on direct current (DC) shocks, with regard to; female, EF levels, diabetes treatment
(P < 0.050). Those who did not receive the hot shot and were not diabetic received more DC
shock (P = 0.019). The prevalence of subjects who did no need DC shock was significantly higher
among male subjects who had good EF and acceptable diabetic treatment. Multiple logistic
regression showed that PAC arrhythmia did not have a significant effect on receiving DC shock
during CAGB [0.84 (0.25, 2.85), (P = 0.780)]. Having poor EF increased the risk of receiving DC
shock among subjects by 2.81 [(1.69, 4.69), (P ? 0.001)] (P < 0.001). Among the diabetic
subjects, receiving insulin decreased the risk of receiving DC shock by 0.54 (0.29, 0.98)
(P = 0.042).
CONCLUSION: It was concluded that single antegrade hot shot following cold cardioplegia was
not particularly effective in the CABG group. TWBC will decrease the need for DC shock.
