Author/Authors :
Shemirani، Hassan نويسنده Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran , , Khanjani، Reza نويسنده Resident, Hypertension Research Center, Isfahan Cardiovascular Research Institute , Isfahan University of Medical Sciences, Isfahan, Iran , , Mohammadi Sichani، Mehrdad نويسنده , , Mozafarpour، Sarah نويسنده Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan , , Rabbani، Majid نويسنده Resident, Hypertension Research Center, Isfahan Cardiovascular Research Institute , Isfahan University of Medical Sciences, Isfahan, Iran , , SHAHABI، Javad نويسنده Resident of Cardiology ,
Abstract :
BACKGROUND: Percutaneous nephrolithotomy is the treatment of choice in large and staghorn
renal stones, and myocardial infarction is one the possible complications during and after the
surgery. We investigated if renal and skeletal muscle injury, caused by percutaneous
nephrolithotomy, can cause elevation in cardiac troponins (cTn).
METHODS: This study was conducted on otherwise healthy patients with renal stone undergoing
percutaneous nephrolithotomy. A baseline 12-lead electrocardiogram, echocardiography, and
cTn assessment confirmed no cardiac pathology in any patients. Cardiac troponins T (cTnT) and
I (cTnI), and also creatine kinase (CK) were assessed before and after surgery.
RESULTS: A total of 55 patients (69.1% males, mean age: 40.5 ± 13.8 year) were included. Serum
creatinine level ranged from 0.7 to 1.3 mg/dl (mean = 1.03 ± 0.17). The level of CK was
significantly increased by 469.5 ± 201.4 U/l (P < 0.001), and no positive cTnT or cTnI was
observed after surgery.
CONCLUSION: The results of the present study showed that renal cell injury, caused by
percutaneous nephrolithotomy, is not associated with elevated cardiac troponins. These findings
show that increasing troponins in patients undergoing percutaneous nephrolithotomy indicate a
cardiovascular pathology.
