Title of article :
Association between markers of systemic inflammation, oxidative stress, lipid profiles, and insulin resistance in pregnant women
Author/Authors :
Asemi، Zatollah نويسنده Department of Nutrition and Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan , , Jazayeri، Shima نويسنده Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran , , Najafi، Mohammad نويسنده Assistant Professor, Department of Biochemistry, School of Medicine, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran , , Samimi، Mansooreh نويسنده Assistant Professor, Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran , , Shidfar، Farzad نويسنده School of Health, Tehran University of Medical Sciences, Tehran, IR Iran , , Tabassi، Zohreh نويسنده Assistant Professor, Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran , , Shahaboddin، MohamadEsmaeil نويسنده Assistant Professor, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran , , ESMAILLZADEH، AHMAD نويسنده ,
Abstract :
BACKGROUND: Increased levels of pro-inflammatory factors, markers of oxidative stress and
lipid profiles are known to be associated with several complications. The aim of this study was to
determine the association of markers of systemic inflammation, oxidative stress and lipid
profiles with insulin resistance in pregnant women in Kashan, Iran.
METHODS: In a cross-sectional study, serum high sensitivity C-reactive protein (hs-CRP), tumor
necrosis factor-alpha (TNF-?), fasting plasma glucose (FPG), serum insulin, 8-oxo-7,
8-dihydroguanine (8-oxo-G), total cholesterol, triglyceride, High density lipoprotein-cholesterol
(HDL-cholesterol), and plasma total antioxidant capacity (TAC) were measured among 89
primigravida singleton pregnant women aged 18-30 years at 24-28 weeks of gestation. Pearson’s
correlation and multiple linear regressions were used to assess their relationships with
homeostatic model assessment of insulin resistance (HOMA-IR).
RESULTS: We found that among biochemical indicators of pregnant women, serum hs-CRP and
total cholesterol levels were positively correlated with HOMA-IR (B = 0.05, P = 0.006 for
hs-CRP and B = 0.006, P = 0.006 for total cholesterol). These associations remained significant
even after mutual effect of other biochemical indicators were controlled (B = 0.04, P = 0.01 for
hs-CRP and B = 0.007, P = 0.02 for total cholesterol). Further adjustment for body mass index
made the association of hs-CRP and HOMA-IR disappeared; however, the relationship for total
cholesterol remained statistically significant.
CONCLUSION: Our findings showed that serum total cholesterol is independently correlated
with HOMA-IR score. Further studies are needed to confirm our findings.
