Author/Authors :
Samieinasab، Mohammad Reza نويسنده Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran , , Shahraki، Mohammad Reza نويسنده Associate Professor, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , , Samieinasab، Fatemah نويسنده Ayatollah Golpayegani Hospital, Qom University of Medical Sciences, Qom, Iran , , Najafi، Somayeh نويسنده Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract :
BACKGROUND: Anabolic-androgenic steroids have been associated with several side effects
range. This experimental study was conducted to evaluate the effects of nandrolone decanoate
(ND, an anabolic steroid) on lipid profile and liver enzymes in rats in Iran.
METHODS: Forty adult male and female of Wistar strain rats were randomly assigned to four
groups of 10 animals each: male control, female control, ND-male treated (15 mg/kg b.w./day),
and ND-female treated (15 mg/kg b.w./day). Serum concentrations of total cholesterol (TC),
triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein
cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were
measured in all studied groups.
RESULTS: Treating rats with ND (case group) resulted in a significant elevation of TC
(69.4 ± 8.7), TG (101.6 ± 32.9) and ALT (72.2 ± 13.8) and significant reduction of LDL
(6.4 ± 2.6) and AST (138.7 ± 19.4) as compared to control group in female rats. ND
supplementation (case group) significantly increased TC (64.4 ± 6.2), AST (255.0 ± 32.0), and
ALT (84.3 ± 3.8) in comparison with the control group in male rats.
CONCLUSION: Overall, our result indicated that the ND use can cause a negative effect on lipid
profile and liver enzyme in rats.
