Author/Authors :
Salehi، Mohammad Saied نويسنده Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran , , Tamadon، Amin نويسنده Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University & Stem Cell and Transgenic Technology Research Center, Shiraz Uni Tamadon, Amin , Jafarzadeh Shirazi، Mohammad Reza نويسنده Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran , , Namavar، Mohammad Reza نويسنده Histomorphometry and Stereology Research Center , Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz , , Zamiri، Mohammad Javad نويسنده Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran ,
Abstract :
Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the
sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin
inhibitory hormone (GnIH) initiated a revolution in the field of reproductive
physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine-
amide (RFamide)-related peptides (RFRPs), indicated a similar function.
Subsequently, further works conducted in various laboratories worldwide have
shown that these neuropeptides inhibit the hypothalamic-hypophyseal axis. This review
discusses the role of RFRPs in mammalian reproductive processes.
