Evaluation of early alterations in transmitral diastolic flow and tissue Doppler imaging findings of the septal and lateral segments of the left ventricle in the early period after coronary angioplast

BACKGROUND: We aimed to evaluate subepicardial and subendocardial left ventricular (LV) functions in patients with single coronary artery lesion at an early stage after percutaneous coronary intervention (PCI). METHODS: Patients with left anterior descending (LAD) lesion (n = 40) were evaluated. Subjects underwent PCI and at least one coronary stent was placed. Before and one month after PCI, patients underwent echocardiography. The ordinary Doppler indicators including E wave deceleration time, A velocity and E velocity as well as the pulsed-wave tissue Doppler imaging (PW-TDI) parameters (Aa, Ea and Sa velocity) were measured. The findings before and after intervention were compared. RESULTS: E wave deceleration time was the only factor that significantly improved in ordinary Doppler and other parameters such as A velocity and E velocity did not show any changes. Among TDI parameters, Aa velocity and Ea velocity in septum area improved significantly but despite an increase in Sa velocity in septum, it was not statistically significant. Ea velocity significantly improved in lateral area but Aa and Sa velocity insignificantly increased. CONCLUSION: In patients with coronary artery disease, the systolic and diastolic function is impaired. It is simply diagnosable by TDI. Although the systolic function impairment is remained after PCI, the diastolic function considerable improved after angioplasty. Our study showed that diastolic function of left ventricle improved over time. In contrast with other studies, in this study, Aa velocity significantly improved one month after revascularization.