Author/Authors :
Rogha، Mehran نويسنده MD, Assistant Professor, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan , , Nikvarz، Marjan نويسنده Assistant Researcher, Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran , , Pourmoghaddas، Zahra نويسنده MD, General Practitioner, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan , , Shirneshan، Keivan نويسنده Pathologist, Isfahan Shariati Hospital, Isfahan, Iran , , Dadkhah، Davood نويسنده Assistant Researcher, Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran , , Pourmoghaddas، Masoud نويسنده MD, Professor of Interventional Cardiology, Chamran Heart Hospital, Isfahan University of Medical Sciences, Isfahan ,
Abstract :
BACKGROUND: There is still controversy about association of Helicobacter pylori (H. pylori)
infection with coronary heart disease (CHD). This study designed to evaluate this association in
a sample of Iranians Population.
METHODS: Medical and drug history as well as fasting blood samples of 112 consecutive
patients who were candidate for coronary angiography were taken on catheterization day.
Fasting blood samples were used to measure C-reactive protein (CRP), anti H. pylori
immunoglobulin G (anti H. pylori IgG) and interlukine-6 (IL6). According to angiography
reports, participants were divided into patients with (n = 62) or without CHD (n = 43). To
compare the association between H. pylori infection with CHD, multivariate logistic regression
tests were used by adjusting sex and age, age and sex plus history of diabetes mellitus (DM),
Dyslipidemia (DLP), and/or hypertension (HTN), CRP status and IL-6 level.
RESULTS: Sixty two patients with CHD and 43 participants without CHD were enrolled in the
present study. The mean ages of patients with and without CHD were 62.4 ± 9.5 and 59.0 ± 10.5
years respectively. Multivariate logistic regression analysis after adjusting for history of DM
and/or DLP and/or HTN plus CRP status and IL-6 level showed significant association of H.
pylori infection with CHD (OR 3.18, 95%CI 1.08-9.40).
CONCLUSION: H. pylori infection is one of the probable risk factors for CHD independent of
history of DM, DLP, HTN, CRP status and IL-6 level.
