Author/Authors :
Hosseinzadeh Atar، Mohammad Javad نويسنده Associate Professor, Department of Nutrition, Tehran University of Medical Sciences International Campus, Tehran, Iran , , Hajianfar، Hossein نويسنده Department of Nutrition, Tehran University of Medical Sciences International Campus , , Bahonar، Ahmad نويسنده Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences ,
Abstract :
BACKGROUND: Hypertension is a condition normally detected in people with type II diabetes.
It eventually leads to cardiovascular diseases in the patient. Visfatin is an adipocytokine which is
secreted from adipose tissue and can affect the inflammatory reaction and also serum lipid
levels. Additionally, omega-3 inhibits the accumulation of fat and formation of insulin
resistance. The current study tried to investigate the effects of omega-3 on blood pressure
compared to placebo and the relationship between serum visfatin levels and blood pressure.
METHODS: A total number of 71 women with type II diabetes were randomly assigned to
2 groups to receive either omega-3 capsules or placebo capsules. In the first step, a
questionnaire consisting age, height, weight, waist and hip circumferences, and systolic and
diastolic blood pressure was filled out for each subject. Blood samples were then collected for
laboratory tests. The next step was to conduct 8 weeks of intervention. All variables, except age,
were measured again after the intervention. Hip circumference was considered as the maximum
circumference of the buttocks. Waist circumference was measured by placing a tape horizontally
across the abdomen at the end of a normal exhalation. Laboratory tests included the assessment
of visfatin, glucose, and glycated hemoglobin (HbA1c) concentrations. Lipid profile, i.e. low
density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG), and cholesterol,
was also assessed. Using SPSS18, data obtained from the study was analyzed by a variety of
appropriate statistical tests.
RESULTS: There was a significant change in mean differences of systolic and diastolic blood
pressure. Blood pressure showed a significant reduction in the omega-3 group compared to the
placebo group. However, no significant changes were observed in systolic and diastolic blood
pressure before and after the intervention (P > 0.05).
CONCLUSION: Based on the results of this study, a daily consumption of omega-3 is suggested
for patients with type II diabetes.
