Title of article :
Antibacterial and physical properties of calcium–phosphate and calcium–fluoride nanocomposites with chlorhexidine
Author/Authors :
Cheng، نويسنده , , Lei and Weir، نويسنده , , Michael D. and Xu، نويسنده , , Hockin H.K. and Kraigsley، نويسنده , , Alison M. and Lin، نويسنده , , Nancy J. and Lin-Gibson، نويسنده , , Sheng and Zhou، نويسنده , , Xuedong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
11
From page :
573
To page :
583
Abstract :
Objectives us studies have developed calcium phosphate and fluoride releasing composites. Other studies have incorporated chlorhexidine (CHX) particles into dental composites. However, CHX has not been incorporated in calcium phosphate and fluoride composites. The objectives of this study were to develop nanocomposites containing amorphous calcium phosphate (ACP) or calcium fluoride (CaF2) nanoparticles and CHX particles, and investigate Streptococcus mutans biofilm formation and lactic acid production for the first time. s exidine was frozen via liquid nitrogen and ground to obtain a particle size of 0.62 μm. Four nanocomposites were fabricated with fillers of: nano ACP; nano ACP + 10% CHX; nano CaF2; nano CaF2 + 10% CHX. Three commercial materials were tested as controls: a resin-modified glass ionomer, and two composites. S. mutans live/dead assay, colony-forming unit (CFU) counts, biofilm metabolic activity, and lactic acid were measured. s CHX fillers to ACP and CaF2 nanocomposites greatly increased their antimicrobial capability. ACP and CaF2 nanocomposites with CHX that were inoculated with S. mutans had a growth medium pH > 6.5 after 3 d, while the control commercial composites had a cariogenic pH of 4.2. Nanocomposites with CHX reduced the biofilm metabolic activity by 10–20 folds and reduced the acid production, compared to the controls. CFU on nanocomposites with CHX were three orders of magnitude less than that on commercial composite. Mechanical properties of nanocomposites with CHX matched a commercial composite without fluoride. icance vel calcium phosphate and fluoride nanocomposites could be rendered antibacterial with CHX to greatly reduce biofilm formation, acid production, CFU and metabolic activity. The antimicrobial and remineralizing nanocomposites with good mechanical properties may be promising for a wide range of tooth restorations with anti-caries capabilities.
Keywords :
Dental nanocomposite , Calcium Phosphate , Stress-bearing , Chlorhexidine , S. mutans biofilm , Caries inhibition , Calcium fluoride
Journal title :
Dental Materials
Serial Year :
2012
Journal title :
Dental Materials
Record number :
2317984
Link To Document :
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