Author/Authors :
-، - نويسنده Department of Anatomy and Cell biology, Birjand University of Medical Sciences, Birjand, Iran. Kermani, Tayyebeh , -، - نويسنده Pharmacological Research Center of Medicinal Plant, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Mousavi, Seyyed Hadi , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Shemshian, Maryam , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Norouzy, Abdolreza , -، - نويسنده Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Beijing, China. Mazidi, Mohsen , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Moezzi, Atefeh , -، - نويسنده Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Moghiman, Toktam , -، - نويسنده Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Ghayour-Mobarhan, Majid , -، - نويسنده Division of Medical Education, Brighton & Sussex Medical School, Rm 342, Mayfield House, University of Brighton, BN1 9PH, United Kingdom Ferns, Gordon. A.
Abstract :
Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome. Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. The serum PAB assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention. Results: There was a significant (p=0.035) reduction in serum PAB between week 0 to week 6 and also from week 0 to week 12. Conclusion: Saffron supplements can modulate serum PAB in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.
